Bendroflumethiazide Drug ( Medicine) Information
How to Take Bendroflumethiazide
Take Bendroflumethiazide exactly as prescribed by health care provider. Bendroflumethiazide is generally available in market in the form Tablets 5 mg . Instruct patient before using Bendroflumethiazide to take drug exactly as prescribed. If dose is missed it should be taken within 1 hr. Warn patient not to double up on doses. If there is not a substantive clinical response to increases in the daily dose, check for proper pump function and catheter patency. The daily maintenance of Bendroflumethiazide dose may be reduced 10% to 20% if patients experience side effects.
Dosage Instructions for Bendroflumethiazide Drug
Adjunctive therapy for edema associated with CHF, hepatic cirrhosis, and corticosteroid and estrogen therapy; treatment of edema associated with various forms of renal dysfunction (eg, nephrotic syndrome, acute glomerulonephritis, chronic renal failure); management of hypertension.
Contraindications for Bendroflumethiazide Drug
Anuria, hypersensitivity to other sulfonamide-derived drugs.
Interactions of Bendroflumethiazide with other drugs
Alcohol, barbiturates, narcotics: May potentiate orthostatic hypotension.
Anticoagulants (eg, warfarin): May decrease anticoagulant effects. May need to adjust dose of anticoagulant.
Antigout medications: May require dosage adjustments caused by increase in uric acid levels.
Amphotericin B, corticosteroid, corticotropin: May intensify electrolyte imbalance, especially hypokalemia.
Bile acid sequestrants: May reduce bendroflumethiazide absorption; give thiazide at least 1 hr before or 4 to 6 hr after bile acid sequestrant.
Calcium salts: May decrease calcium excretion.
Diazoxide: May cause hyperglycemia, hyperuricemia, and antihypertensive effects.
Digitalis glycosides: Diuretic-induced hypokalemia and hypomagnesemia may precipitate digitalis-induced arrhythmias.
Ganglionic or peripheral adrenergic blocking agents: Bendroflumethiazide may potentiate effects. May need to adjust the dose.
Lithium: May decrease renal excretion of lithium.
Loop diuretics: Synergistic effects may result in profound diuresis and serious electrolyte abnormalities.
MAO inhibitors: May enhance hypotensive effects.
NSAIDs: May reduce effects of bendroflumethiazide.
Nondepolarizing muscle relaxants: May potentiate effects of these agents.
Pressor amines (eg, norepinephrine), anesthetic, and preanesthetic agents:
Reduce dosage and discontinue bendroflumethiazide 1 wk prior to surgery.
Sulfonylureas, insulin: May decrease hypoglycemic effect of sulfonylureas.
Because bendroflumethiazide may elevate blood glucose levels, dosage of sulfonylureas or insulin may need to be increased.
What are the Side Effects of Bendroflumethiazide -
Like other medicines, Bendroflumethiazide can cause side effects. Some of the more common side effects of Bendroflumethiazide include
* Restlessness (not uncommon); dizziness, vertigo, paresthesia, headache
* Purpura, exfoliative dermatitis, pruritus, ecchymosis, urticaria, necrotizing angitis (vasculitis, cutaneous vasculitis) (occasionally); photosensitivity; rash.
* Xanthopsia, transient blurred vision (occasionally).
* Nausea, vomiting, cramping, anorexia (not uncommon); diarrhea, constipation, gastric, irritation, abdominal bloating, sialoadenitis (occasionally); pancreatitis.
* Leukopenia; agranulocytosis; thrombocytopenia; hemolytic anemia; aplastic anemia
* Jaundice (intrahepatic cholestatic); hepatitis (occasionally).
* Hyperglycemia, glucosuria, metabolic acidosis, hyperuricemia (occasionally).
Warnings and precautions before taking Bendroflumethiazide :
* Instruct patient to inform health care provider if any of the following occur: muscle pain, weakness, or cramps; persistent nausea or vomiting; excessive thirst; unexplained tiredness; drowsiness; increased heart rate; unexplained joint pain; abnormal skin sensations.
* The safety and efficay of Bendroflumethiazide medicine have not been studied in children and adolescents.
* Advise women before using Bendroflumethiazide to inform health care provider if pregnant, planning to become pregnant, or breastfeeding while taking Bendroflumethiazide Insulin is recommended to maintain blood glucose levels. during pregnancy. Prolonged severe neonatal hypoglycemia can occur if sulfonylureas are administered at time of delivery.
* Warn patient before using Bendroflumethiazide not to discontinue medication abruptly. Explain that hallucinations or seizures may occur.
* Instruct patient before using Bendroflumethiazide to report the following symptoms to health care provider: dizziness, nausea, hypotension, urinary frequency, retention, painful urination, headache, seizures, weakness.
What if Overdose of Bendroflumethiazide ?
If you think you or anyone else taken overdose of Bendroflumethiazide , immediately telephone your doctor or contact your local or regional Poisons Information Centre Seek medical attention immediately. You may need urgent medical attention. Temporary elevation of BUN, GI irritation, lethargy progressing to coma with minimal depression of respiration and CV function and without significant serum electrolyte changes or dehydration
are may be the overdose symptoms of Bendroflumethiazide .
What if Missed Dose of Bendroflumethiazide ?
If you miss a dose of Bendroflumethiazide medicine and you remember within an hour or so, take the dose immediately. If you do not remember until later, skip the dose you missed and go back to your regular schedule. Do not double doses.
Storage Conditions for Bendroflumethiazide :
Store tablets at controlled room temperature (59° to 86°F). Protect from excessive heat.
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How would you expect this to affect blood ph and respiratory rate and is this a state of acidosis or alkalosis?
Patient ingested E Coli and was diagnosed with food poisoning and has had chronic diarrhea for the past 24 hours. The patient has a medical history of Chron’s Disease. The diarrhea has been going on nonstop for 24 hours. How would you expect this to affect the blood ph and respiratory rate? Is the patient suffering from a state of acidosis or alkalosis and would you expect this to be related to metabolic or respiratory disorder and why?
To answer this, you need more information. Renal function and pulmonary function will influence the end result. Also the activity of the Crohn’s needs to be established, and whether an enteroenteric fistula is present.
However: Assuming he has non-secretory diarrhea (ie not bicarbonate wasting as in a villous adenoma of the colon), then the primary event will be a metabolic alkalosis due to volume contraction. If his kidney function is normal, he will attempt to retain sodium (along with bicarbonate) and lose potassium in the urine. Due to some fairly complex actions in the proximal and distal tubule, he will effectively retain bicarbonate, leading to the alkalosis.
If he has normal pulmonary function, he will probably not have a respiratory compensation (it would have to be hypoventilation, which is hard to do unless other things are going on (such as sedatives, altered level of conciousness etc).
As time goes by, and if the diarrhea persists, in the absence of volume replacement, he will ultimately develop pre-renal azotemia, which will affect the metabolic component (he will develop a metabolic acidosis that is distinct from the metabolic alkalosis he already has).
If he goes on to develop hypeovolemic shock, other things come into play – etc etc etc.
Its not always straighforward. I hope this helps.
